COVID-19 and pregnancy: A narrative review on the use of convalescent plasma

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a global concern, considering both the severity of the disease, with a high mortality rate compared to that of other influenza-like viral illnesses, and the lack of a specific, effective treatment. Pregnant women with coronavirus disease 2019 (COVID-19) represent a further challenge for clinicians. Indeed, although the majority of them are asymptomatic or their SARS-CoV-2 disease has a mild to moderate course, in some cases this viral infection is accompanied by severe respiratory symptoms. In such a critical clinical setting, the already limited therapeutic armamentarium available for COVID-19 patients is further restricted in pregnant women because of the risk of fetal toxicity especially during the first trimester of gestation. Among the treatment options, the use of convalescent plasma has gained increasing interest from investigators in pregnant women, given the initial positive reports on safety and efficacy aspects of this treatment in critically ill COVID-19 patients. However, the literature data are scanty and almost limited to single case reports, considering that pregnant women are usually excluded from trials on convalescent plasma. In this narrative review, we will critically discuss the current literature evidence on the use of hyperimmune plasma during pregnancies complicated by COVID-19.Copyright © 2021 AME Publishing Company.

IoT Systems for Healthy and Safe Life Environments

The past two years have been sadly marked by the worldwide spread of the SARS-Cov-19 pandemic. The first line of defense against this and other pandemic threats is to respect interpersonal distances, use masks, and sanitize hands, air, and objects. Some of these countermeasures are becoming part of our daily lives, as they are now considered good practices to reduce the risk of infection and contagion. In this context, we present Safe Place, a modular system enabled by Internet of Things (IoT) that is designed to improve the safety and healthiness of living environments. This system combines several sensors and actuators produced by different vendors with self-regulating procedures and Artificial Intelligence (AI) algorithms to limit the spread of viruses and other pathogens, and increase the quality and comfort offered to people while minimizing the energy consumption.We discuss the main objectives of the system and its implementation, showing preliminary results that assess its potentials in enhancing the conditions of living and working spaces. © 2022 IEEE.